7 Best Running Shoes for Neuropathy 2021 Reviewed

The best running shoes for neuropathy will ease the force on your feet from repetitive stress that would cause tingling, numbness, muscle weakness, or nerve damage or dysfunction. 

Best Running Shoes for Neuropathy

These shoes will relieve your neuropathy pain just like with the shoes for metatarsalgia – but they must be comfortable, with ergonomic sole, and be lightweight.

You’ll require anatomical arch support and great cushioning. The insole should be removed to enable the use of custom orthotics, like for plantar fasciitis shoes. 

Reviews: Top 7 Best Running Shoes for Neuropathy in 2021

1. Orthofeet Neuropathy Ventura Foot & Heel Pain Relief – #1 Pick

Orthofeet Neuropathy Ventura has a rubber sole and leather materials with guarantee comfort. The orthopedic shoes are both stylish and comfortable – and its pain-free. 

Orthofeet Neuropathy Ventura Proven Foot & Heel Pain Relief View on Amazon

Orthofeet Neuropathy Ventura will ease the pain from neuropathy, foot pain, heel pain, and plantar fasciitis. The orthotic insoles, better cushioning, and ergonomic sole design gives a great advantage. 

The shoe has extended widths to increase comfort with its non-binding uppers and this will provide some perfect fit. Its therapeutic build will ease alleviate joint stress to increase stability. 

It has great foam padding and an interior lining that’s smooth to offer protection and comfort will sensitive feet – great diabetic or arthritis shoes. 

The shoe’s non-binding fit, roomy and wide toebox provides comfortable rides while also easing pressure and pain arising from swollen feet, hammertoes, and bunions. 

It offers pressure-point protection, great arch support, while also giving you a non-binding fit – for a stable, soften and ergonomic riding. 


  • It has an extra-depth build plus removable insoles that can allow custom orthotics and have ample space. 
  • The upper is very durable since it’s designed from leather 
  • The orthotic insole provides top comfort and support that’ll finally improve the foot motion. 
  • Has a spacious toe-box and orthotic insole
  • he Orthofeet Neuropathy Ventura reduces pain with its spacious toe box for relaxed feet
  • Its rubber outsole effectively grips on various surfaces while walking or running


  • The shoes upper is built from leather that could feel uncomfortable

Read Also: Flip Flops for Walking Long Distances

2. Gravity G-Defy Women’s Mighty Walk for Pain – #2 Pick

Gravity G-Defy is fabric-and-synthetic Neuropathy shoes. For renewed innovative energy, you’ll get spring system from the VersoShock Technology. 

Gravity G-Defy Women’s Mighty Walk for Pain View on Amazon

The shoe’s spacious toe box makes them suitable for diabetes and bunions since they have limited wiggle room left. Also, check these brooks running shoes for flat feet. 

The Gravity G-Defy has a seamless interior that’ll work well for anyone whose feet are sensitive while also easing irritation coming from diabetic neuropathy. 

The shoe has a sleek and powerful build – with a breathable and lightweight design leading to some secure fit. Despite having a low-profile design, the shoe will ease the Neuropathy pain. 

The sole is the front-rocker type that’ll effectively support your midfoot and hence relieve or prevent plantar fasciitis. Also, with the insoles being removable, you can use your custom orthotics. 

Gravity G-Defy offers great toe wiggle room and comfortable toe-box – reducing the chances of acquiring blisters and pain. You’ll be well supported around the midfoot. 


  • The insoles are removable allowing the inclusion of custom orthotics 
  • Its midfoot is excellent supported 
  • The Neuropathy running shoe provides a gentle and secure fit with its non-toxic and tie-less silicone laces.
  • Finally, the shies are simple to clean, hypoallergenic, waterproof, and flexible. 
  • Great impact and shock reduction thanks to the VersoShock technology


  • Low-profile build 

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3. Adrenaline GTS 19 Men’s Brooks Running Shoe – #3 Pick

Adrenaline GTS 19 has an innovative GuideRails support system that’ll limit excessive movement to prevent hurting the knees and your lower back. 

Adrenaline GTS 19 Men’s Brooks Running Shoe View on Amazon

The DNA BioMoGo LOFT offers greater underfoot softness while also maintaining excellent durability and responsiveness. Its 3D-Fit Print on the upper mesh gives a modern appearance. 

Adrenaline GTS 19’s weigh, drop, and upper are innovative to give the shoe an amazing outlook. Further, the GuideRails gives the show a Holistic Supportoutlook – great durability and comfort. 

Adrenaline GTS 19 must your go-to shoe for cinder or hard soil trails for plantar fasciitis, flat, treadmill, and road – including for their daily training. 

The GuideRails system will effectively prevent overpronation – and excellent shoe update. You can cover long runs gon gup to 40 miles or above while also correcting your motion or movement. 

The engineered mesh making the shoes upper (breathable) also gives a snug and adaptable fit. The smooth and soft lining provided comfort to stop skin irritations. 

The heel counter and midfoot cage provide excellent foot locking while also the collar and tongue are excellently padded for great comfort. 

You’ll get a straightened gait while also mitigating overpronation through the guide rail support, lateral heel, and medial midfoot – while also maintaining the durability and cushioning. 


  • The shoes’ lacing system plus the roomy toe box ease your discomfort 
  • Very breathable and flexible 
  • The 12mm heel drop may not, however, offers the required satisfaction
  • Great stability and durability 
  • The shoes effectively stretch to the feet while also being breathable and waterproof – through the suitable upper mesh 


  • None found

Read Also: Shoes for Spartan Race

4. ASICS Gel-Venture 6 Men’s Neuropathy Running Shoe

Gel-Venture 6 has received great challenges and updates to make them great walking shoes – with an innovative mesh upper while also preventing bad odors and moist feet.

ASICS Gel-Venture 6 Men's Neuropathy Running Shoe View on Amazon

Gel-Venture 6 has a superior mesh upper that increases the support and breathability. The removable insole and midsole technology offers a great fit and cushioning. 

The shoe favors people with a neutral gait while the foot won’t rotate outward and inward – with a natural motion to ease the impact of over-supination and overpronation for all your running cycles. 

Gel-Venture 6 will be excellent for people having an average arch and when you need to ease the ball of foot pain but will also work well for a moderate-high arch. 

The additional reinforcement on both sides of the Gel-Venture 6 plus the heel collar also preventing foot sliding either down or up when you’re running on an incline. 

The shoe lugs provide a sturdy grip while the heel area is covered by the gel cushioning to protect your hips and spine – you’ll notice the 19mm heel height. 

Gel-Venture 6 has the nylon upper offers great durability with the material reinforcements – the shoes will be great for trail training due to its toe “layers”. 


  • The shoe’s rubber is the high-abrasion type and it’ll assist in absorbing the shock created from your running.
  • For shock-absorption, it includes Gel® technology – also ensures durability
  • The shoe’s outsole offers you some solid-support bar which will allow it to effectively stretches on your midfoot.
  • Therefore, the runner’s step will be slightly stable since there is limited twisting
  • Gel-Venture 6 is comfortable running footwear with great grip and durability thanks to AHAR outsole and removable sock liner.


  • None found 

Read Also: Shoes for Degenerative Disc Disease

5. Skechers Afterburn for Men Lace-up and Memory-Foam Sneaker

Skechers Afterburn is a great Neuropathy running shoe. The upper (mesh fabric), synthetic, and smooth leather – great training sneaker – with great overlay accents, stitching, and perforated details. 

Skechers Afterburn for Men Lace-up and Memory-Foam Sneaker View on Amazon 

Skechers Afterburn has Memory Foam insole, fabric lining, tongue, and padded collar plus its built-in heel (1 ½ “), and rubber sole that have high-traction. 

The Neuropathy running shoe ill work great for anyone weighing 350+ lbs to cover even 8 miles per day. However, its memory foam is not effectively functional even on hard concrete floors. 

The neuropathy shoes offer supportive overlays and a padded collar – besides its mesh upper for comfort plus the cushioned mesh tongue. The underfoot offers comfort plus the memory foam insole. 


  • The shoe offers great shock absorption thanks to the thick midsole for comfortable walking and running 
  • Comfort due to the padded collar and mesh upper 
  • Additional cofort due to the insole with memory foam 
  • Great traction due to its suitable outsole


  • Outsole isn’t very durable 


The best running shoes for neuropathy will work great for wide-footed runners with pliable and soft upper. Besides, the shoe’s lining must be seam-free and have extra-foam padding. 

The shoe’s insole has arch support that’s anatomical with cushioned heel area to effectively contour the feet. It’ll ease foot pain thanks to the insole that’ll improve comfort. 

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